Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection
L Shen, RF Siliciano - Journal of allergy and clinical immunology, 2008 - Elsevier
Although highly active antiretroviral therapy (HAART) can reduce HIV-1 viremia to levels that
are below the limit of detection of clinical assays, the virus persists in reservoirs, and trace
levels of free virions can be found in the plasma. Whether this residual viremia represents
ongoing cycles of replication continuing despite HAART or simply the release of virus from
stable reservoirs has been controversial. Here we summarize the evidence that HAART can
stop ongoing cycles of replication. The evidence comes from a detailed analysis of the …
are below the limit of detection of clinical assays, the virus persists in reservoirs, and trace
levels of free virions can be found in the plasma. Whether this residual viremia represents
ongoing cycles of replication continuing despite HAART or simply the release of virus from
stable reservoirs has been controversial. Here we summarize the evidence that HAART can
stop ongoing cycles of replication. The evidence comes from a detailed analysis of the …