New insights into HIV assembly and trafficking
M Balasubramaniam, EO Freed - Physiology, 2011 - journals.physiology.org
Physiology, 2011•journals.physiology.org
Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated
by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly
translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag
trafficking is currently one of the least understood aspects of HIV-1 replication. In this review,
we highlight the current understanding of the cellular machinery involved in Gag trafficking
and virus assembly.
by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly
translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag
trafficking is currently one of the least understood aspects of HIV-1 replication. In this review,
we highlight the current understanding of the cellular machinery involved in Gag trafficking
and virus assembly.
Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly translocates to membrane to orchestrate particle production. The cell biology of HIV-1 Gag trafficking is currently one of the least understood aspects of HIV-1 replication. In this review, we highlight the current understanding of the cellular machinery involved in Gag trafficking and virus assembly.
American Physiological Society