Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)–1/TIM4 interaction as a therapeutic strategy in a dendritic cell–induced peanut allergy model
BS Feng, X Chen, SH He, PY Zheng, J Foster… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Recent reports indicate that dendritic cell (DC)–derived T-cell
immunoglobulin and mucin domain molecule (TIM)–4 plays an important role in the initiation
of TH2 polarization. This study aims to elucidate the mechanisms of peanut allergy mediated
by microbial products and DCs and the relationship between peanut allergy and TIM4.
METHODS: Mouse bone marrow–derived DCs (BMDCs) were generated and exposed to
cholera toxin (CT) or/and peanut extract (PE) for 24 hours and then adoptively transferred to …
immunoglobulin and mucin domain molecule (TIM)–4 plays an important role in the initiation
of TH2 polarization. This study aims to elucidate the mechanisms of peanut allergy mediated
by microbial products and DCs and the relationship between peanut allergy and TIM4.
METHODS: Mouse bone marrow–derived DCs (BMDCs) were generated and exposed to
cholera toxin (CT) or/and peanut extract (PE) for 24 hours and then adoptively transferred to …