[HTML][HTML] Selective in Vivo Inhibition of Mitogen-activated Protein Kinase Activation Using Cell-permeable Peptides* 210
BR Kelemen, K Hsiao, SA Goueli - Journal of Biological Chemistry, 2002 - ASBMB
The extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein
kinases (MAPKs), is essential for cellular proliferation and differentiation, and thus there
exists great interest to develop specific and selective inhibitors of this enzyme. Whereas
small molecule inhibitors PD098095 and U0126 have been used to study MAPK/ERK
kinase (MEK), their target selectivity has been questioned recently. The cross-reactivity of
ATP-directed inhibitors with other protein kinases prompted us to develop structure-based …
kinases (MAPKs), is essential for cellular proliferation and differentiation, and thus there
exists great interest to develop specific and selective inhibitors of this enzyme. Whereas
small molecule inhibitors PD098095 and U0126 have been used to study MAPK/ERK
kinase (MEK), their target selectivity has been questioned recently. The cross-reactivity of
ATP-directed inhibitors with other protein kinases prompted us to develop structure-based …