Current perspectives of natural killer cell education by MHC class I molecules
From the early days of natural killer (NK) cell research, it was clear that MHC genes
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject
transplanted allogeneic bone marrow and to kill tumour cells. Although several mechanisms
that are involved in this' education'process have been clarified, most of the mechanisms
have still to be identified. Here, we review the current understanding of the processes that
are involved in NK cell education, including how the host MHC class I molecules regulate …
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject
transplanted allogeneic bone marrow and to kill tumour cells. Although several mechanisms
that are involved in this' education'process have been clarified, most of the mechanisms
have still to be identified. Here, we review the current understanding of the processes that
are involved in NK cell education, including how the host MHC class I molecules regulate …
Abstract
From the early days of natural killer (NK) cell research, it was clear that MHC genes controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject transplanted allogeneic bone marrow and to kill tumour cells. Although several mechanisms that are involved in this 'education' process have been clarified, most of the mechanisms have still to be identified. Here, we review the current understanding of the processes that are involved in NK cell education, including how the host MHC class I molecules regulate responsiveness and receptor repertoire formation in NK cells and the signalling pathways that are involved.
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