Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer
Context Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian
cancer have produced conflicting results. Objective To determine the relationships between
BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS),
progression-free survival (PFS), chemotherapy response, and whole-exome mutation rate in
ovarian cancer. Design, Setting, and Patients Observational study of multidimensional
genomics and clinical data on 316 high-grade serous ovarian cancer cases that were made …
cancer have produced conflicting results. Objective To determine the relationships between
BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS),
progression-free survival (PFS), chemotherapy response, and whole-exome mutation rate in
ovarian cancer. Design, Setting, and Patients Observational study of multidimensional
genomics and clinical data on 316 high-grade serous ovarian cancer cases that were made …