TRPV1 expression and activity during retinoic acid-induced neuronal differentiation
JEL Andaloussi-Lilja, J Lundqvist, A Forsby - Neurochemistry international, 2009 - Elsevier
The transient receptor potential vanilloid subtype 1 (TRPV1) is a Ca2+-permeable channel
primarily expressed in dorsal root ganglion neurons. Besides its function in thermogenic
nociception and neurogenic inflammation, TRPV1 is involved in cell migration, cytoskeleton
re-organisation and in neuronal guidance. To explore the TRPV1 level and activity during
conditions for neuronal maturation, TRPV1-expressing SHSY5Y neuroblastoma cells were
differentiated into a neuronal phenotype using all-trans-retinoic acid (RA). We show that RA …
primarily expressed in dorsal root ganglion neurons. Besides its function in thermogenic
nociception and neurogenic inflammation, TRPV1 is involved in cell migration, cytoskeleton
re-organisation and in neuronal guidance. To explore the TRPV1 level and activity during
conditions for neuronal maturation, TRPV1-expressing SHSY5Y neuroblastoma cells were
differentiated into a neuronal phenotype using all-trans-retinoic acid (RA). We show that RA …