[HTML][HTML] Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

Y Laouar, FS Sutterwala, L Gorelik, RA Flavell - Nature immunology, 2005 - nature.com
Y Laouar, FS Sutterwala, L Gorelik, RA Flavell
Nature immunology, 2005nature.com
Interferon-γ and interleukin 12 produced by the innate arm of the immune system are
important regulators of T helper type 1 (TH1) cell development, but signals that negatively
regulate their expression remain controversial. Here we show that transforming growth factor-
β (TGF-β) controlled TH1 differentiation through the regulation of interferon-γ produced by
natural killer (NK) cells. Blockade of TGF-β signaling in NK cells caused the accumulation of
a large pool of NK cells secreting copious interferon-γ, responsible for TH1 differentiation …
Abstract
Interferon-γ and interleukin 12 produced by the innate arm of the immune system are important regulators of T helper type 1 (TH1) cell development, but signals that negatively regulate their expression remain controversial. Here we show that transforming growth factor-β (TGF-β) controlled TH1 differentiation through the regulation of interferon-γ produced by natural killer (NK) cells. Blockade of TGF-β signaling in NK cells caused the accumulation of a large pool of NK cells secreting copious interferon-γ, responsible for TH1 differentiation and protection from leishmania infection. In contrast, blockade of TGF-β signaling in dendritic cells did not affect dendritic cell homeostasis or interleukin 12 production, thus indicating a previously undescribed demarcation of the function of TGF-β in NK cells versus dendritic cells.
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