Potential regulatory function of human dendritic cells expressing indoleamine 2, 3-dioxygenase

DH Munn, MD Sharma, JR Lee, KG Jhaver… - Science, 2002 - science.org
DH Munn, MD Sharma, JR Lee, KG Jhaver, TS Johnson, DB Keskin, B Marshall, P Chandler…
Science, 2002science.org
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of
human APCs that express indoleamine 2, 3-dioxygenase (IDO) and inhibit T cell
proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by
coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC)
lineage, IDO-mediated suppressor activity was present in fully mature as well as immature
CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these …
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
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