[CITATION][C] Prolactin and IgG‐Prolactin Complex Levels in Patients with Rheumatic Arthritis
S Leiderman, M Gurfinkiel, S Damilano… - Annals of the New …, 2002 - Wiley Online Library
S Leiderman, M Gurfinkiel, S Damilano, RAS Lago, S Martins, F Rosman, A Hamaui…
Annals of the New York Academy of Sciences, 2002•Wiley Online LibraryOBJECTIVE Our goal was to establish in rheumatic patients (1) the role of prolactin (PRL) as
potent proinflammatory agent in patients, as has been observed in vitro, and (2) the
incidence and significance of IgG-PRL immune complex as a diminishing factor of clinical
manifestations, as well as an autoimmune activity marker. METHODS Twenty-two patients
(20 females and 2 males), ages 32 to 79 years (mean: 53.7), diagnosed with rheumatic
arthritis (RA) by the American College of Rheumatology (ACR) criteria, were examined …
potent proinflammatory agent in patients, as has been observed in vitro, and (2) the
incidence and significance of IgG-PRL immune complex as a diminishing factor of clinical
manifestations, as well as an autoimmune activity marker. METHODS Twenty-two patients
(20 females and 2 males), ages 32 to 79 years (mean: 53.7), diagnosed with rheumatic
arthritis (RA) by the American College of Rheumatology (ACR) criteria, were examined …
OBJECTIVE
Our goal was to establish in rheumatic patients (1) the role of prolactin (PRL) as potent proinflammatory agent in patients, as has been observed in vitro, and (2) the incidence and significance of IgG-PRL immune complex as a diminishing factor of clinical manifestations, as well as an autoimmune activity marker.
METHODS
Twenty-two patients (20 females and 2 males), ages 32 to 79 years (mean: 53.7), diagnosed with rheumatic arthritis (RA) by the American College of Rheumatology (ACR) criteria, were examined. Fifteen of the 20 women were postmenopausal and five premenopausal. The disease evolution period was 0.5 to 27 years (mean: 8.5 years). All the patients were under treatment with NSAIDs. Corticosteroids were administrated in seven, hydroxycloroquine (HCQ) in four, and metotrexate (MTX) in eleven of the cases.
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