[HTML][HTML] Oxidation of high density lipoproteins: II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins AI and AII
Human high density lipoproteins (HDL) can reduce cholesteryl ester hydroperoxides to the
corresponding hydroxides (Sattler W., Christison JK, and Stocker, R.(1995) Free Radical
Biol. & Med. 18, 421–429). Here we demonstrate that this reducing activity extended to
hydroperoxides of phosphatidylcholine, was similar in HDL 2 and HDL 3, was independent
of arylesterase and lecithin: cholesteryl acyltransferase activity, was unaffected by sulfhydryl
reagents, and was expressed by reconstituted particles containing apoAI or apoAII only, as …
corresponding hydroxides (Sattler W., Christison JK, and Stocker, R.(1995) Free Radical
Biol. & Med. 18, 421–429). Here we demonstrate that this reducing activity extended to
hydroperoxides of phosphatidylcholine, was similar in HDL 2 and HDL 3, was independent
of arylesterase and lecithin: cholesteryl acyltransferase activity, was unaffected by sulfhydryl
reagents, and was expressed by reconstituted particles containing apoAI or apoAII only, as …