Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon

B Mackness, MI Mackness, S Arrol… - British journal of …, 1997 - ncbi.nlm.nih.gov
B Mackness, MI Mackness, S Arrol, W Turkie, PN Durrington
British journal of pharmacology, 1997ncbi.nlm.nih.gov
The hydrolysis of organophosphate pesticides (OP) and nerve gases by serum paraoxonase
(PON1) is an important factor determining their toxicity to mammals including man. The
PON1 gene contains 2 polymorphic sites at amino acid positions 55 (L→ M) and 192 (G→ A,
classically defined as the A and B genotypes) which result in several alloenzymes of PON1
in human serum.
Abstract
1. The hydrolysis of organophosphate pesticides (OP) and nerve gases by serum paraoxonase (PON1) is an important factor determining their toxicity to mammals including man. The PON1 gene contains 2 polymorphic sites at amino acid positions 55 (L→ M) and 192 (G→ A, classically defined as the A and B genotypes) which result in several alloenzymes of PON1 in human serum.
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