[HTML][HTML] A detailed molecular belt model for apolipoprotein AI in discoidal high density lipoprotein
JP Segrest, MK Jones, AE Klon, CJ Sheldahl… - Journal of Biological …, 1999 - ASBMB
Apolipoprotein AI (apoA-I) is the principal protein of high density lipoprotein particles (HDL).
ApoA-I contains a globular N-terminal domain (residues 1–43) and a lipid-binding C-
terminal domain (residues 44–243). Here we propose a detailed model for the smallest
discoidal HDL, consisting of two apoA-I molecules wrapped beltwise around a small patch of
bilayer containing 160 lipid molecules. The C-terminal domain of each monomer is ringlike,
a curved, planar amphipathic α helix with an average of 3.67 residues per turn, and with the …
ApoA-I contains a globular N-terminal domain (residues 1–43) and a lipid-binding C-
terminal domain (residues 44–243). Here we propose a detailed model for the smallest
discoidal HDL, consisting of two apoA-I molecules wrapped beltwise around a small patch of
bilayer containing 160 lipid molecules. The C-terminal domain of each monomer is ringlike,
a curved, planar amphipathic α helix with an average of 3.67 residues per turn, and with the …