[HTML][HTML] Patients with chronic hepatitis B infection display deficiency of plasmacytoid dendritic cells with reduced expression of TLR9
Q Xie, HC Shen, NN Jia, H Wang, LY Lin, BY An… - Microbes and …, 2009 - Elsevier
Chronic hepatitis B virus (HBV) infection is a complex interaction between replicating
noncytopathic virus and dysregulatory host antiviral immunity. Plasmacytoid dendritic cells
(pDCs) contribute to innate antiviral immunity via secreting type I interferons. Toll-like
receptor (TLR) 9 is involved in major pattern recognition receptors expressed in pDCs. The
frequency of pDCs and TLR9 expression in peripheral blood mononuclear cells (PBMC)
was determined, using flow cytometry. IFN-α production by PBMC was evaluated in vitro in …
noncytopathic virus and dysregulatory host antiviral immunity. Plasmacytoid dendritic cells
(pDCs) contribute to innate antiviral immunity via secreting type I interferons. Toll-like
receptor (TLR) 9 is involved in major pattern recognition receptors expressed in pDCs. The
frequency of pDCs and TLR9 expression in peripheral blood mononuclear cells (PBMC)
was determined, using flow cytometry. IFN-α production by PBMC was evaluated in vitro in …