Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines

AJ Gehring, SA Xue, ZZ Ho, D Teoh, C Ruedl… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Virus-specific T cells capable of controlling HBV and eliminating
hepatocellular carcinoma (HCC) expressing HBV antigens are deleted or dysfunctional in
patients with chronic HBV or HBV-related HCC. The goal of this study was to determine if T
cell receptor (TCR) gene transfer can reconstitute HBV-specific T cell immunity in
lymphocytes of chronic HBV patients and investigate whether HCC cells with natural HBV–
DNA integration can be recognized by genetically modified T cells. METHODS: We used …