[HTML][HTML] Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
H Lu, CL Dalgard, A Mohyeldin, T McFate… - Journal of Biological …, 2005 - ASBMB
Continuous hydroxylation of the HIF-1 transcription factor α subunit by oxygen and 2-
oxoglutarate-dependent dioxygenases promotes decay of this protein and thus prevents the
transcriptional activation of many genes involved in energy metabolism, angiogenesis, cell
survival, and matrix modification. Hypoxia blocks HIF-1α hydroxylation and thus activates
HIF-1α-mediated gene expression. Several nonhypoxic stimuli can also activate HIF-1,
although the mechanisms involved are not well known. Here we show that the glucose …
oxoglutarate-dependent dioxygenases promotes decay of this protein and thus prevents the
transcriptional activation of many genes involved in energy metabolism, angiogenesis, cell
survival, and matrix modification. Hypoxia blocks HIF-1α hydroxylation and thus activates
HIF-1α-mediated gene expression. Several nonhypoxic stimuli can also activate HIF-1,
although the mechanisms involved are not well known. Here we show that the glucose …