[HTML][HTML] PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation
F Liang, J Liang, WQ Wang, JP Sun, E Udho… - Journal of biological …, 2007 - ASBMB
Phosphatase of regenerating liver 3 (PRL3) is overexpressed in a variety of tumors, and
high levels of PRL3 expression are associated with tumorigenesis and metastasis.
Consistent with an oncogenic role for PRL3, we show that ectopic PRL3 expression
promotes cell proliferation and invasion. However, little is known about the molecular basis
for PRL3 function. Obtaining this knowledge is vital for understanding PRL3-mediated
disease processes and for the development of novel anticancer therapies targeted to PRL3 …
high levels of PRL3 expression are associated with tumorigenesis and metastasis.
Consistent with an oncogenic role for PRL3, we show that ectopic PRL3 expression
promotes cell proliferation and invasion. However, little is known about the molecular basis
for PRL3 function. Obtaining this knowledge is vital for understanding PRL3-mediated
disease processes and for the development of novel anticancer therapies targeted to PRL3 …