Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy
OC Andronesi, D Mintzopoulos, J Struppe… - Journal of Magnetic …, 2008 - Elsevier
We propose a solid-state NMR method that maximizes the advantages of high-resolution
magic-angle-spinning (HRMAS) applied to intact biopsies when compared to more
conventional liquid-state NMR approaches. Theoretical treatment, numerical simulations
and experimental results on intact human brain biopsies are presented. Experimentally, it is
proven that an optimized adiabatic TOBSY (TOtal through Bond correlation SpectroscopY)
solid-state NMR pulse sequence for two-dimensional 1H–1H homonuclear scalar-coupling …
magic-angle-spinning (HRMAS) applied to intact biopsies when compared to more
conventional liquid-state NMR approaches. Theoretical treatment, numerical simulations
and experimental results on intact human brain biopsies are presented. Experimentally, it is
proven that an optimized adiabatic TOBSY (TOtal through Bond correlation SpectroscopY)
solid-state NMR pulse sequence for two-dimensional 1H–1H homonuclear scalar-coupling …