[HTML][HTML] Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4
Recent studies have initiated a paradigm shift in the understanding of the function of heat
shock proteins (HSP). It is now clear that HSP can and do exit mammalian cells, interact with
cells of the immune system, and exert immunoregulatory effects. We recently demonstrated
that exogenously added HSP70 possesses potent cytokine activity, with the ability to bind
with high affinity to the plasma membrane, elicit a rapid intracellular Ca 2+ flux, activate NF-
κB, and up-regulate the expression of pro-inflammatory cytokines in human monocytes …
shock proteins (HSP). It is now clear that HSP can and do exit mammalian cells, interact with
cells of the immune system, and exert immunoregulatory effects. We recently demonstrated
that exogenously added HSP70 possesses potent cytokine activity, with the ability to bind
with high affinity to the plasma membrane, elicit a rapid intracellular Ca 2+ flux, activate NF-
κB, and up-regulate the expression of pro-inflammatory cytokines in human monocytes …