Sick chaperones, cellular stress, and disease
AJL Macario, EC de Macario - New England Journal of Medicine, 2005 - Mass Medical Soc
AJL Macario, EC de Macario
New England Journal of Medicine, 2005•Mass Medical SocThis review discusses the structure and function of molecular chaperones, with emphasis on
their role in rescuing misfolded proteins. It also includes a discussion of the diseases in
which abnormalities of these caretaker molecules or their molecular partners have been
found.
their role in rescuing misfolded proteins. It also includes a discussion of the diseases in
which abnormalities of these caretaker molecules or their molecular partners have been
found.
This review discusses the structure and function of molecular chaperones, with emphasis on their role in rescuing misfolded proteins. It also includes a discussion of the diseases in which abnormalities of these caretaker molecules or their molecular partners have been found.
The New England Journal Of Medicine