[HTML][HTML] Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
AYM Chan, CLM Soltys, ME Young, CG Proud… - Journal of Biological …, 2004 - ASBMB
A necessary mediator of cardiac myocyte enlargement is protein synthesis, which is
controlled at the levels of both translation initiation and elongation. Eukaryotic elongation
factor-2 (eEF2) mediates the translocation step of peptide-chain elongation and is inhibited
through phosphorylation by eEF2 kinase. In addition, p70S6 kinase can regulate protein
synthesis by phosphorylating eEF2 kinase or via phosphorylation of ribosomal protein S6.
We have recently shown that eEF2 kinase is also controlled by phosphorylation by AMP …
controlled at the levels of both translation initiation and elongation. Eukaryotic elongation
factor-2 (eEF2) mediates the translocation step of peptide-chain elongation and is inhibited
through phosphorylation by eEF2 kinase. In addition, p70S6 kinase can regulate protein
synthesis by phosphorylating eEF2 kinase or via phosphorylation of ribosomal protein S6.
We have recently shown that eEF2 kinase is also controlled by phosphorylation by AMP …