Expression of tissue inhibitor of matrix metalloproteinase-1 in aging of transgenic mouse liver
Y Zhang, X Chen, WU Di, X Zhang, LÜ Yang… - Chinese medical …, 2006 - journals.lww.com
Background Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) is related to the aging of
many organs, but few data are available on the change of TIMP-1 in liver aging. The
purpose of this study was to investigate the expression and role of TIMP-1, matrix
metalloproteinase-2 (MMP-2) and MMP-9 in the process of natural aging in the livers of
normal and transgenic mice, and to detect the effects of TIMP-1 on oxidative level and anti-
oxidative ability of the livers of transgenic young mice. Methods Normal and transgenic mice …
many organs, but few data are available on the change of TIMP-1 in liver aging. The
purpose of this study was to investigate the expression and role of TIMP-1, matrix
metalloproteinase-2 (MMP-2) and MMP-9 in the process of natural aging in the livers of
normal and transgenic mice, and to detect the effects of TIMP-1 on oxidative level and anti-
oxidative ability of the livers of transgenic young mice. Methods Normal and transgenic mice …