[HTML][HTML] Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice
Y Liao, ON Shikapwashya, E Shteyer… - Journal of Biological …, 2004 - ASBMB
The early growth response-1 transcription factor (Egr-1) is induced as part of the immediate-
early gene expression response during early liver regeneration. In the studies reported here
the functional significance of EGR-1 expression during liver regeneration was examined by
characterizing the hepatic regenerative response to partial hepatectomy in Egr-1 null mice.
The results of these studies showed that liver regeneration in Egr-1 null mice is impaired.
Although activation of interleukin-6-STAT3 signaling, regulation of expression of hepatic …
early gene expression response during early liver regeneration. In the studies reported here
the functional significance of EGR-1 expression during liver regeneration was examined by
characterizing the hepatic regenerative response to partial hepatectomy in Egr-1 null mice.
The results of these studies showed that liver regeneration in Egr-1 null mice is impaired.
Although activation of interleukin-6-STAT3 signaling, regulation of expression of hepatic …