Limited potential of circulating haemopoietic stem cells

HS Micklem, N Anderson, E Ross - Nature, 1975 - nature.com
HS Micklem, N Anderson, E Ross
Nature, 1975nature.com
IT has long been known that animals irradiated with a lethal dose may recover if the spleen
is shielded during exposure1, or if normal bone marrow or spleen cells are subsequently
injected intravenously2. Recovery has been shown to be the result of repopulation of the
damaged haemopoietic tissues by stem cells from the donor3. It was later found that cells
with at least some of the characteristics of stem cells were present in the blood of normal
mice4–6. These characteristics included the formation of spleen colonies and the ability to …
Abstract
IT has long been known that animals irradiated with a lethal dose may recover if the spleen is shielded during exposure1, or if normal bone marrow or spleen cells are subsequently injected intravenously2. Recovery has been shown to be the result of repopulation of the damaged haemopoietic tissues by stem cells from the donor3. It was later found that cells with at least some of the characteristics of stem cells were present in the blood of normal mice4–6. These characteristics included the formation of spleen colonies and the ability to promote recovery from lethal irradiation, at least in the short term. Some studies7 have suggested that circulating stem cells are equivalent to those in bone marrow, while others8 have indicated certain differences.
nature.com