[HTML][HTML] Reactive oxygen species stimulates receptor activator of NF-κB ligand expression in osteoblast
X Bai, D Lu, A Liu, Z Zhang, X Li, Z Zou, W Zeng… - Journal of Biological …, 2005 - ASBMB
It has been established that reactive oxygen species (ROS) such as H 2 O 2 or superoxide
anion is involved in bone loss-related diseases by stimulating osteoclast differentiation and
bone resorption and that receptor activator of NF-κB ligand (RANKL) is a critical
osteoclastogenic factor expressed on stromal/osteoblastic cells. However, the roles of ROS
in RANKL expression and signaling mechanisms through which ROS regulates RANKL
genes are not known. Here we report that increased intracellular ROS levels by H 2 O 2 or …
anion is involved in bone loss-related diseases by stimulating osteoclast differentiation and
bone resorption and that receptor activator of NF-κB ligand (RANKL) is a critical
osteoclastogenic factor expressed on stromal/osteoblastic cells. However, the roles of ROS
in RANKL expression and signaling mechanisms through which ROS regulates RANKL
genes are not known. Here we report that increased intracellular ROS levels by H 2 O 2 or …