[HTML][HTML] Activation of the Trk signaling pathway by extracellular zinc: role of metalloproteinases
JJ Hwang, MH Park, SY Choi, JY Koh - Journal of biological chemistry, 2005 - ASBMB
In certain brain regions, extracellular zinc concentrations can rise precipitously as intense
neuronal activity releases large amounts of zinc from the nerve terminals. Although zinc
release has been suggested to play a pathological role, its precise physiological effect is
poorly understood. Here, we report that exposure to micromolar quantities of zinc for only a
few minutes robustly and specifically activated tropomyosin-related kinase (Trk) receptors,
most likely TrkB, in cultured cortical neurons. We further found that Trk activation by zinc is …
neuronal activity releases large amounts of zinc from the nerve terminals. Although zinc
release has been suggested to play a pathological role, its precise physiological effect is
poorly understood. Here, we report that exposure to micromolar quantities of zinc for only a
few minutes robustly and specifically activated tropomyosin-related kinase (Trk) receptors,
most likely TrkB, in cultured cortical neurons. We further found that Trk activation by zinc is …