Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease
Y Ma, M Okamoto, MG Thomas, DP Bogdanos… - Hepatology, 2002 - Elsevier
Prevalence and clinical relevance of antibodies to soluble liver antigen (tRNP (Ser)
Sec/SLA) in autoimmune hepatitis (AIH) have been investigated using partially purified or
prokaryotically expressed antigen. The aim of this study was to improve the detection of anti-
tRNP (Ser) Sec/SLA by establishing an immunoassay that was able to identify antibodies
directed to conformational epitopes and to investigate the clinical implication of this
autoantibody in autoimmune liver disease. By using eukaryotically expressed tRNP (Ser) …
Sec/SLA) in autoimmune hepatitis (AIH) have been investigated using partially purified or
prokaryotically expressed antigen. The aim of this study was to improve the detection of anti-
tRNP (Ser) Sec/SLA by establishing an immunoassay that was able to identify antibodies
directed to conformational epitopes and to investigate the clinical implication of this
autoantibody in autoimmune liver disease. By using eukaryotically expressed tRNP (Ser) …