Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis
AJ Czaja, PT Donaldson, AW Lohse - The American journal of …, 2002 - Elsevier
OBJECTIVE: Antibodies to soluble liver antigen/liver-pancreas are highly specific markers of
type 1 autoimmune hepatitis that have been associated with relapse. Our aim was to
determine if these antibodies are reflective of a genetic predisposition for recrudescent
disease. METHODS: One hundred forty-four white North American patients were evaluated
by an enzyme immunoassay and by Western blot using recombinant soluble liver
antigen/liver-pancreas; 122 were assessed for class II human leukocyte antigens (HLAs) …
type 1 autoimmune hepatitis that have been associated with relapse. Our aim was to
determine if these antibodies are reflective of a genetic predisposition for recrudescent
disease. METHODS: One hundred forty-four white North American patients were evaluated
by an enzyme immunoassay and by Western blot using recombinant soluble liver
antigen/liver-pancreas; 122 were assessed for class II human leukocyte antigens (HLAs) …