[HTML][HTML] The FTO gene rs9939609 obesity-risk allele and loss of control over eating
M Tanofsky-Kraff, JC Han, K Anandalingam… - The American journal of …, 2009 - Elsevier
Background Children with rs9939609 FTO variant alleles (homozygous= AA and
heterozygous= AT) are predisposed to greater adiposity than are those with 2 wild-type
alleles (TT). Objective Because FTO is highly expressed in hypothalamic regions that are
important for appetite, FTO genotype may affect energy balance by influencing eating
behavior. Loss of control (LOC) eating, a behavior commonly reported by overweight youth,
predicts excessive weight gain in children. However, the relation between FTO genotype …
heterozygous= AT) are predisposed to greater adiposity than are those with 2 wild-type
alleles (TT). Objective Because FTO is highly expressed in hypothalamic regions that are
important for appetite, FTO genotype may affect energy balance by influencing eating
behavior. Loss of control (LOC) eating, a behavior commonly reported by overweight youth,
predicts excessive weight gain in children. However, the relation between FTO genotype …