[HTML][HTML] Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice
MM Marsh, VR Walker, LK Curtiss, CL Banka - Journal of lipid research, 1999 - ASBMB
Low density lipoprotein (LDL) receptor-deficient (LDLR–/–) mice consuming a high fat diet
were used to assess the effect of endogenous and exogenous estradiol (E 2) on
atherosclerosis. Sexually mature female mice were ovariectomized (OVX) and implanted
with subcutaneous, slow-release pellets designed to release 6 μg/day of exogenous 17β-
estradiol (17β-E 2), 17α-estradiol (17α-E 2), or placebo (E 2-deficient). Sham-operated
control female (endogenous E 2) and male mice were studied as controls. Aortic …
were used to assess the effect of endogenous and exogenous estradiol (E 2) on
atherosclerosis. Sexually mature female mice were ovariectomized (OVX) and implanted
with subcutaneous, slow-release pellets designed to release 6 μg/day of exogenous 17β-
estradiol (17β-E 2), 17α-estradiol (17α-E 2), or placebo (E 2-deficient). Sham-operated
control female (endogenous E 2) and male mice were studied as controls. Aortic …