The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response
R Joachim, AC Zenclussen, B Polgar, AJ Douglas… - Steroids, 2003 - Elsevier
Stress is known to induce abortions in mice and humans, putatively via increased levels of
abortogenic Th1 cytokines and a decrease of progesterone. Adequate levels of
progesterone exert an antiabortive response through binding to the progesterone-receptor,
which induces the release of progesterone-induced blocking factor (PIBF) from lymphocytes.
PIBF is highly pregnancy-protective by induction of a Th2 biased immune activity. The aim of
this study was to investigate the effect of the progesterone derivative dydrogesterone (6 …
abortogenic Th1 cytokines and a decrease of progesterone. Adequate levels of
progesterone exert an antiabortive response through binding to the progesterone-receptor,
which induces the release of progesterone-induced blocking factor (PIBF) from lymphocytes.
PIBF is highly pregnancy-protective by induction of a Th2 biased immune activity. The aim of
this study was to investigate the effect of the progesterone derivative dydrogesterone (6 …