[HTML][HTML] Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway
Pro-apoptotic protein 24p3, a member of lipocalin family, is induced upon interleukin-3 (IL-3)
deprivation and plays a pivotal role in induction of apoptosis in hematopoietic cells.
However, the molecular mechanism by which IL-3 regulates 24p3 expression remains
largely unknown. Here, we show that 24p3 is a direct target of Foxo3a and that
phosphoinositide 3-kinase (PI3K)/Akt mediates IL-3-repressed 24p3 through regulation of
Foxo3a. Inhibition of the PI3K/Akt (but not MAPK) pathway induced 24p3 expression and …
deprivation and plays a pivotal role in induction of apoptosis in hematopoietic cells.
However, the molecular mechanism by which IL-3 regulates 24p3 expression remains
largely unknown. Here, we show that 24p3 is a direct target of Foxo3a and that
phosphoinositide 3-kinase (PI3K)/Akt mediates IL-3-repressed 24p3 through regulation of
Foxo3a. Inhibition of the PI3K/Akt (but not MAPK) pathway induced 24p3 expression and …