Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion
S Pinilla, E Alt, FJA Khalek, C Jotzu, F Muehlberg… - Cancer letters, 2009 - Elsevier
S Pinilla, E Alt, FJA Khalek, C Jotzu, F Muehlberg, C Beckmann, YH Song
Cancer letters, 2009•ElsevierIn the present study, we investigated whether human adipose tissue derived stem cells
(hASCs) could enhance tumor invasion and whether these hASCs could be a potential
source of CCL5. We observed a significant increase in the number of breast cancer cells that
invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in
the Co-culture and cancer cell invasion was diminished by an antibody against CCL5.
Furthermore, cancer cell invasion in the Co-culture was associated with an elevated level of …
(hASCs) could enhance tumor invasion and whether these hASCs could be a potential
source of CCL5. We observed a significant increase in the number of breast cancer cells that
invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in
the Co-culture and cancer cell invasion was diminished by an antibody against CCL5.
Furthermore, cancer cell invasion in the Co-culture was associated with an elevated level of …
In the present study, we investigated whether human adipose tissue derived stem cells (hASCs) could enhance tumor invasion and whether these hASCs could be a potential source of CCL5. We observed a significant increase in the number of breast cancer cells that invaded the matrigel when Co-cultured with hASCs. We found that hASCs produce CCL5 in the Co-culture and cancer cell invasion was diminished by an antibody against CCL5. Furthermore, cancer cell invasion in the Co-culture was associated with an elevated level of MMP-9 activity. We conclude that CCL5 plays a crucial role for tumor invasion in the interplay of tissue resident stem cells from the fat tissue and breast cancer cells.
Elsevier