Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence.
T Ohtsuka, Y Kitajima, T Takahashi, S Sato… - Hepato …, 2009 - europepmc.org
T Ohtsuka, Y Kitajima, T Takahashi, S Sato, A Miyoshi, N Kohya, K Kitahara, Y Nakafusa…
Hepato-gastroenterology, 2009•europepmc.orgResults The median time for the hepatic recurrence after the operation was 4.9 months
(range 1 to 20.4 months). Among 14 factors, only postoperative infectious complications
significantly accelerated the hepatic recurrence based on a univariate analysis (p= 0.049).
Two more factors, gastric cancer and preoperative tumor marker elevation, had a tendency
to affect the rapid recurrence, but did not show statistical significance (both p= 0.06). A
multivariate analysis revealed that postoperative infectious complications (p= 0.005) and …
(range 1 to 20.4 months). Among 14 factors, only postoperative infectious complications
significantly accelerated the hepatic recurrence based on a univariate analysis (p= 0.049).
Two more factors, gastric cancer and preoperative tumor marker elevation, had a tendency
to affect the rapid recurrence, but did not show statistical significance (both p= 0.06). A
multivariate analysis revealed that postoperative infectious complications (p= 0.005) and …
Results
The median time for the hepatic recurrence after the operation was 4.9 months (range 1 to 20.4 months). Among 14 factors, only postoperative infectious complications significantly accelerated the hepatic recurrence based on a univariate analysis (p= 0.049). Two more factors, gastric cancer and preoperative tumor marker elevation, had a tendency to affect the rapid recurrence, but did not show statistical significance (both p= 0.06). A multivariate analysis revealed that postoperative infectious complications (p= 0.005) and gastric cancer (p= 0.04) were significant and independent factors. Five of 11 patients with gastric cancer suffered from postoperative infectious complications, 4 of which were associated with pancreatic leakage after a pancreatosplenectomy, and all 5 patients had hepatic recurrence within 3 months after the operation.
Conclusions
Postoperative infectious complications are thus considered to accelerate a rapid hepatic recurrence after a gastrectomy for gastric cancer.
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