[PDF][PDF] Pancreatic (B-Cells of GK Rats, a Model of Type 2 Diabetes

Y Ihara, S Toyokuni, K Uchida, H Odaka, T Tanaka… - Diabetes, 1999 - academia.edu
RESEARCH DESIGN AND METHODS Animals. Male GK rats were maintained in the
Takeda Pharmaceutical Research Laboratories (Osaka, Japan). The study sample included
12 male GK rats and 12 male Wistar rats. The animals were given standard laboratory diet
(Oriental Yeast, Tokyo) and tap water ad libitum and were maintained on a 12-h light-and-
dark cycle in an air-conditioned room (22–24 C) during the experiments. The pancreases of
5-, 8-, 12-, and 21-week-old GK rats and the age-matched control Wistar rats (n= 3 for each …