The circadian clock modulates renal sodium handling

S Nikolaeva, S Pradervand, G Centeno… - Journal of the …, 2012 - journals.lww.com
The circadian clock contributes to the control of BP, but the underlying mechanisms remain
unclear. We analyzed circadian rhythms in kidneys of wild-type mice and mice lacking the
circadian transcriptional activator clock gene. Mice deficient in clock exhibited dramatic
changes in the circadian rhythm of renal sodium excretion. In parallel, these mice lost the
normal circadian rhythm of plasma aldosterone levels. Analysis of renal circadian
transcriptomes demonstrated changes in multiple mechanisms involved in maintaining …