[HTML][HTML] HOP/NECC1, a novel regulator of mouse trophoblast differentiation

K Asanoma, H Kato, S Yamaguchi, CH Shin… - Journal of Biological …, 2007 - ASBMB
Homeodomain-only protein/not expressed in choriocarcinoma clone 1 (HOP/NECC1) is a
newly identified gene that modifies the expression of cardiac-specific genes and thereby
regulates heart development. More recently, HOP/NECC1 was reported to be a suppressor
of choriocarcinogenesis. Here, we examined the temporal expression profile of HOP/NECC1
in wild-type mouse placenta. We found that E8. 5–E9. 5 wild-type placenta expressed
HOP/NECC1 in the giant cell and spongiotrophoblast layers. HOP/NECC1 (-/-) placenta …