Met, metastasis, motility and more
C Birchmeier, W Birchmeier, E Gherardi… - … reviews Molecular cell …, 2003 - nature.com
C Birchmeier, W Birchmeier, E Gherardi, GF Vande Woude
Nature reviews Molecular cell biology, 2003•nature.comHepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1—
homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster—
for downstream signalling. Pivotal roles for Met in development and cancer have been
established: Met controls cell migration and growth in embryogenesis; it also controls
growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to …
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1—
homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster—
for downstream signalling. Pivotal roles for Met in development and cancer have been
established: Met controls cell migration and growth in embryogenesis; it also controls
growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to …
Abstract
Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 — homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster — for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.
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