Induction of multiple matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1
I Ozaki, T Mizuta, G Zhao, H Zhang, T Yoshimura… - Hepatology …, 2003 - Elsevier
Matrix metalloproteinases (MMPs) have been implicated in progression of hepatocellular
carcinoma (HCC), as have hepatocyte growth factor (HGF) and its c-Met receptor. We
investigated regulation of MMP gene expression by HGF in human HCC. Expression of
mRNAs encoding MMPs, HGF and c-Met receptor was examined by quantitative reverse
transcription-polymerase chain reaction (RT-PCR) in human HCC and in five human HCC
cell lines. HCC cells were treated with HGF, and mRNA expression for MMPs and Ets-1 …
carcinoma (HCC), as have hepatocyte growth factor (HGF) and its c-Met receptor. We
investigated regulation of MMP gene expression by HGF in human HCC. Expression of
mRNAs encoding MMPs, HGF and c-Met receptor was examined by quantitative reverse
transcription-polymerase chain reaction (RT-PCR) in human HCC and in five human HCC
cell lines. HCC cells were treated with HGF, and mRNA expression for MMPs and Ets-1 …