[HTML][HTML] Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome
TL Wu, K Töpfer, SW Lin, H Li, A Bian, XY Zhou… - Molecular Therapy, 2012 - cell.com
TL Wu, K Töpfer, SW Lin, H Li, A Bian, XY Zhou, KA High, HCJ Ertl
Molecular Therapy, 2012•cell.comUsing a mouse model we show that self-complementary (sc) adeno-associated virus (AAV)
vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene
product-specific CD8+ T cell and antibody responses compared to corresponding single-
stranded (ss) AAV vectors. These data suggest that the higher and more rapidly appearing
amounts of transgene product achieved with scAAV vectors may increase detrimental
immune responses in gene transfer recipients.
vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene
product-specific CD8+ T cell and antibody responses compared to corresponding single-
stranded (ss) AAV vectors. These data suggest that the higher and more rapidly appearing
amounts of transgene product achieved with scAAV vectors may increase detrimental
immune responses in gene transfer recipients.
Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8+ T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data suggest that the higher and more rapidly appearing amounts of transgene product achieved with scAAV vectors may increase detrimental immune responses in gene transfer recipients.
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