[HTML][HTML] Differential transcriptional regulation by mouse single-minded 2s
RP Metz, HI Kwak, T Gustafson, B Laffin… - Journal of biological …, 2006 - ASBMB
Single-minded 1 and 2 are unique members of the basic helix-loop-helix Per-Arnt-Sim family
as they are transcriptional repressors. Here we report the identification and transcriptional
characterization of mouse Sim2s, a splice variant of Sim2, which is missing the carboxyl
Pro/Ala-rich repressive domain. Sim2s is expressed at high levels in kidney and skeletal
muscle; however, the ratio of Sim2 to Sim2s mRNA differs between these tissues. Similar to
full-length Sim2, Sim2s interacts with Arnt and to a lesser extent, Arnt2. The effects of Sim2s …
as they are transcriptional repressors. Here we report the identification and transcriptional
characterization of mouse Sim2s, a splice variant of Sim2, which is missing the carboxyl
Pro/Ala-rich repressive domain. Sim2s is expressed at high levels in kidney and skeletal
muscle; however, the ratio of Sim2 to Sim2s mRNA differs between these tissues. Similar to
full-length Sim2, Sim2s interacts with Arnt and to a lesser extent, Arnt2. The effects of Sim2s …