[HTML][HTML] Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators
A Chapman-Smith, JK Lutwyche… - Journal of Biological …, 2004 - ASBMB
The basic helix-loop-helix (bHLH) PAS transcriptional regulators control critical
developmental and metabolic processes, including transcriptional responses to stimuli such
as hypoxia and environmental pollutants, mediated respectively by hypoxia inducible factors
(HIF-α) and the dioxin (aryl hydrocarbon) receptor (DR). The bHLH proteins contain a basic
DNA binding sequence adjacent to a helix-loop-helix dimerization domain. Dimerization
among bHLH. PAS proteins is additionally regulated by the PAS region, which controls the …
developmental and metabolic processes, including transcriptional responses to stimuli such
as hypoxia and environmental pollutants, mediated respectively by hypoxia inducible factors
(HIF-α) and the dioxin (aryl hydrocarbon) receptor (DR). The bHLH proteins contain a basic
DNA binding sequence adjacent to a helix-loop-helix dimerization domain. Dimerization
among bHLH. PAS proteins is additionally regulated by the PAS region, which controls the …