[HTML][HTML] KIF1Bβ functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36. 2 by inducing apoptotic cell death
AK Munirajan, K Ando, A Mukai, M Takahashi… - Journal of Biological …, 2008 - ASBMB
Deletion of the distal region of chromosome 1 frequently occurs in a variety of human
cancers, including aggressive neuroblastoma. Previously, we have identified a 500-kb
homozygously deleted region at chromosome 1p36. 2 harboring at least six genes in a
neuroblastoma-derived cell line NB1/C201. Among them, only KIF1Bβ, a member of the
kinesin superfamily proteins, induced apoptotic cell death. These results prompted us to
address whether KIF1Bβ could be a tumor suppressor gene mapped to chromosome 1p36 …
cancers, including aggressive neuroblastoma. Previously, we have identified a 500-kb
homozygously deleted region at chromosome 1p36. 2 harboring at least six genes in a
neuroblastoma-derived cell line NB1/C201. Among them, only KIF1Bβ, a member of the
kinesin superfamily proteins, induced apoptotic cell death. These results prompted us to
address whether KIF1Bβ could be a tumor suppressor gene mapped to chromosome 1p36 …