The clearance of a monoclonal anti-DNA antibody following administration of DNA in normal and autoimmune mice
FS Jones, DS Pisetsky, RJ Kurlander - Clinical immunology and …, 1986 - Elsevier
To study the assembly of DNA-anti-DNA complexes in vivo, we have measured the
clearance from blood and organ localization of a murine IgG2a monoclonal anti-DNA
antibody, called 6 0, following the infusion of DNA intravenously or intraperitoneally.
Intraperitoneal DNA caused a profound acceleration of 6 0 anti-DNA clearance that was
dose dependent and demonstrable after the infusion of as little as 1.9 μg per gram of body
weight of single-stranded DNA. The antibody was cleared primarily in the liver without …
clearance from blood and organ localization of a murine IgG2a monoclonal anti-DNA
antibody, called 6 0, following the infusion of DNA intravenously or intraperitoneally.
Intraperitoneal DNA caused a profound acceleration of 6 0 anti-DNA clearance that was
dose dependent and demonstrable after the infusion of as little as 1.9 μg per gram of body
weight of single-stranded DNA. The antibody was cleared primarily in the liver without …