Maximizing tumor immunity with fractionated radiation
D Schaue, JA Ratikan, KS Iwamoto… - International Journal of …, 2012 - Elsevier
PURPOSE: Technologic advances have led to increased clinical use of higher-sized
fractions of radiation dose and higher total doses. How these modify the pathways involved
in tumor cell death, normal tissue response, and signaling to the immune system has been
inadequately explored. Here we ask how radiation dose and fraction size affect antitumor
immunity, the suppression thereof, and how this might relate to tumor control. METHODS
AND MATERIALS: Mice bearing B16-OVA murine melanoma were treated with up to 15 Gy …
fractions of radiation dose and higher total doses. How these modify the pathways involved
in tumor cell death, normal tissue response, and signaling to the immune system has been
inadequately explored. Here we ask how radiation dose and fraction size affect antitumor
immunity, the suppression thereof, and how this might relate to tumor control. METHODS
AND MATERIALS: Mice bearing B16-OVA murine melanoma were treated with up to 15 Gy …