Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
S Demaria, B Ng, ML Devitt, JS Babb… - International Journal of …, 2004 - Elsevier
PURPOSE: Ionizing radiation can reduce tumor growth outside the field of radiation, known
as the abscopal effect. Although it has been reported in multiple malignancies, the abscopal
effect remains a rare and poorly understood event. Ionizing radiation generates
inflammatory signals and, in principle, could provide both tumor-specific antigens from dying
cells and maturation stimuli that are necessary for dendritic cells' activation of tumor-specific
T cells. We therefore tested the hypothesis that the abscopal effect elicited by radiation is …
as the abscopal effect. Although it has been reported in multiple malignancies, the abscopal
effect remains a rare and poorly understood event. Ionizing radiation generates
inflammatory signals and, in principle, could provide both tumor-specific antigens from dying
cells and maturation stimuli that are necessary for dendritic cells' activation of tumor-specific
T cells. We therefore tested the hypothesis that the abscopal effect elicited by radiation is …