Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
L Yang, Y Wang, H Mao, S Fleig, A Omenetti… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: Factors released during liver injury, such as platelet derived growth
factor-BB (PDGF), promote accumulation of myofibroblastic hepatic stellate cells (MFB) that
drive the pathogenesis of cirrhosis. The hedgehog (Hh) pathway regulates remodeling of
other injured tissues. This study evaluates the hypothesis that autocrine production of Sonic
hedgehog (Shh) promotes MFB growth. METHODS: Primary rat hepatic stellate cells (HSC)
were treated without or with PDGF, a pharmacologic inhibitor of PDGF-regulated kinases …
factor-BB (PDGF), promote accumulation of myofibroblastic hepatic stellate cells (MFB) that
drive the pathogenesis of cirrhosis. The hedgehog (Hh) pathway regulates remodeling of
other injured tissues. This study evaluates the hypothesis that autocrine production of Sonic
hedgehog (Shh) promotes MFB growth. METHODS: Primary rat hepatic stellate cells (HSC)
were treated without or with PDGF, a pharmacologic inhibitor of PDGF-regulated kinases …