Foxf1+/− mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury

VV Kalinichenko, D Bhattacharyya, Y Zhou… - Hepatology, 2003 - Elsevier
Previous studies have shown that haploinsufficiency of the splanchnic and septum
transversum mesoderm Forkhead Box (Fox) f1 transcriptional factor caused defects in lung
and gallbladder development and that Foxf1 heterozygous (+/−) mice exhibited defective
lung repair in response to injury. In this study, we show that Foxf1 is expressed in hepatic
stellate cells in developing and adult liver, suggesting that a subset of stellate cells
originates from septum transversum mesenchyme during mouse embryonic development …