[HTML][HTML] The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis

T Kisseleva, DA Brenner - Journal of hepatology, 2012 - Elsevier
Liver fibrosis is an outcome of chronic liver injury of any etiology. It is manifested by
extensive deposition of extracellular matrix (ECM) proteins that produce a fibrous scar in the
injured liver. Bone marrow (BM) cells may play an important role in pathogenesis and
resolution of liver fibrosis. BM cells contribute to the inflammatory response by TGF-β1
secretion and activation of liver resident myofibroblasts. Moreover, BM itself can serve as a
source of collagen expressing cells, eg BM-derived fibrocytes and mesenchymal …