[HTML][HTML] Complement Factor H–ligand interactions: Self-association, multivalency and dissociation constants
SJ Perkins, R Nan, K Li, S Khan, A Miller - Immunobiology, 2012 - Elsevier
Factor H (FH) is the major plasma regulator of the central complement protein C3b in the
alternative pathway of complement activation. The elucidation of the FH interactions with five
major ligands (below) is complicated by their weak μM dissociation constants KD and FH
multivalency. We present the first survey of all the KD values for the major FH–ligand
interactions and critically review their physiological significance.
alternative pathway of complement activation. The elucidation of the FH interactions with five
major ligands (below) is complicated by their weak μM dissociation constants KD and FH
multivalency. We present the first survey of all the KD values for the major FH–ligand
interactions and critically review their physiological significance.